20-012 · EVIDENCE A · SOURCE-SENSITIVE

For children with severe eczema or egg allergy, don’t avoid peanuts — introduce them early under medical guidance, but never feed whole peanuts.

孩子有严重湿疹或鸡蛋过敏,别躲着花生,按医生指导早点加上,但绝不能喂整粒

Source cost

A jar of peanut butter costs just a few dozen yuan. Feeding it a few times a week is easy to fit into a routine. Before starting, though, a doctor’s evaluation is required.

Source return

In a randomized trial of 640 high‑risk infants, those who ate peanuts regularly from 4 to 11 months of age had a peanut allergy rate of only 1.9% by age 5, compared with 13.7% in the group that completely avoided peanuts. Among children already showing a weak positive skin test at enrollment, the rates were 10.6% versus 35.3%. Avoiding peanuts actually raises the risk of allergy. However, whole peanuts must never be given, as they can block the airway. A total of 530 infants had negative skin tests at entry, while 98 had weakly positive results.

Evidence grade

A

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What the source says

The source summarizes the return this way: “In a randomized trial of 640 high‑risk infants, those who ate peanuts regularly from 4 to 11 months of age had a peanut allergy rate of only 1.9% by age 5, compared with 13.7% in the group that completely avoided peanuts. Among children already showing a weak positive skin test at enrollment, the rates were 10.6% versus 35.3%. Avoiding peanuts actually raises the risk of allergy. However, whole peanuts must never be given, as they can block the airway. A total of 530 infants had negative skin tests at entry, while 98 had weakly positive results.” Evidence grade A. The original states the population, caveats, and sources; this is not a personal forecast.

THE ENGLISH EDITION

Original recommendation and evidence

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12. For children with severe eczema or egg allergy, don’t avoid peanuts — introduce them early under medical guidance, but never feed whole peanuts.

Cost: A jar of peanut butter costs just a few dozen yuan. Feeding it a few times a week is easy to fit into a routine. Before starting, though, a doctor’s evaluation is required.

In plain terms: In a randomized trial of 640 high‑risk infants, those who ate peanuts regularly from 4 to 11 months of age had a peanut allergy rate of only 1.9% by age 5, compared with 13.7% in the group that completely avoided peanuts. Among children already showing a weak positive skin test at enrollment, the rates were 10.6% versus 35.3%. Avoiding peanuts actually raises the risk of allergy. However, whole peanuts must never be given, as they can block the airway. A total of 530 infants had negative skin tests at entry, while 98 had weakly positive results.

Benefit: The LEAP trial involved 640 infants aged 4–11 months with severe eczema, egg allergy, or both. One group ate peanut products regularly while the other avoided them entirely; at 60 months, only 1.9% of the eaters had a peanut allergy versus 13.7% of avoiders (P<0.001). Among 98 children with a weak positive skin test at entry, 10.6% of eaters were allergic versus 35.3% of avoiders (P=0.004). No serious adverse events differed between groups.

Evidence grade: A

Sources: Du Toit G, Roberts G, Sayre PH, et al. (2015). Randomized trial of peanut consumption in infants at risk for peanut allergy. New England Journal of Medicine, 372(9), 803-813. <https://doi.org/10.1056/NEJMoa1414850>; National Health Commission of China (NHC) General Office (2020). Core information on infant and young child feeding health education. <https://www.gov.cn/zhengce/zhengceku/2020-08/01/content_5531915.htm>; Perkin MR et al. (2016). Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants. New England Journal of Medicine, 374(18), 1733-1743. <https://doi.org/10.1056/NEJMoa1514210> (The general infant trial EAT in the remarks)

Notes: Peanuts must be given only as thinned peanut butter or powdered form mixed into food — never as whole nuts. The Health Commission clearly states: “Whole peanuts, nuts, jelly, and similar foods can be inhaled into the airway and cause choking; infants should avoid them.” For choking first aid, see Section 13, Item 26. This guidance applies only to high‑risk children with severe eczema or egg allergy. A medical assessment is mandatory before introduction; in the LEAP trial, children with a skin‑test reaction greater than 4 mm were excluded. Another study of 1,162 breastfed infants found no significant difference in overall food allergy rates between early‑introduction and standard groups, though a subset showed a clear benefit: 5.6% versus 7.1% (P=0.32) and 2.4% versus 7.3% respectively. Evidence for typical infants is far weaker. Early introduction appears safe, but Chinese official guidelines currently give no recommendation on this point; therefore this advice follows international trial evidence. Keep in mind that LEAP started at 4 months while Chinese practice recommends waiting until 6 months for solids — consult a doctor on timing and method for high‑risk children.

Read the complete Chinese source and notes

12. 孩子有严重湿疹或鸡蛋过敏,别躲着花生,按医生指导早点加上,但绝不能喂整粒

成本: 一罐花生酱几十元。每周喂几次,顺手就做。加之前要带孩子看一次医生,做个评估。

说人话: 有重度湿疹或鸡蛋过敏的婴儿,从 4 到 11 个月起定期吃花生,到 5 岁时花生过敏的只有 1.9%,完全躲开的是 13.7%。皮试已经有点反应的孩子,吃的是 10.6%,躲的是 35.3%。加之前先带孩子看医生。绝不能喂整粒花生,会噎住气管。

收益: 英国 LEAP 随机试验。640 名婴儿入组,条件是有重度湿疹、鸡蛋过敏,或者两样都有。入组时 4 到 11 个月大。随机分成两组,一组定期吃花生制品,一组完全回避,到 60 个月大时看花生过敏率。入组时花生皮试阴性的 530 人里,回避组 13.7% 过敏,吃的组 1.9%(P<0.001)。入组时皮试已经弱阳性的 98 人里,回避组 35.3%,吃的组 10.6%(P=0.004)。两组的严重不良事件没有差别。

证据等级: A

来源: Du Toit G, Roberts G, Sayre PH, 等 (2015). Randomized trial of peanut consumption in infants at risk for peanut allergy. New England Journal of Medicine, 372(9), 803-813. <https://doi.org/10.1056/NEJMoa1414850>;国家卫生健康委办公厅 (2020). 婴幼儿喂养健康教育核心信息. <https://www.gov.cn/zhengce/zhengceku/2020-08/01/content_5531915.htm>;Perkin MR 等 (2016). Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants. New England Journal of Medicine, 374(18), 1733-1743. <https://doi.org/10.1056/NEJMoa1514210>(备注里那项一般婴儿试验 EAT)

备注: **形式只能是花生酱调稀或者花生粉拌进辅食,绝不能给整粒花生。**卫健委的喂养核心信息写得很明白:「整粒花生、坚果、果冻等食物易吸入气管,引起窒息,婴幼儿应当避免食用」。噎住了怎么办见第 13 节第 26 条(有人噎住说不出话)。适用的只是高危孩子:有重度湿疹,或者已经对鸡蛋过敏的那些。**加之前必须先看医生做评估,不要自己在家试**:LEAP 试验入组前给每个孩子做了皮试,皮试反应大于 4 毫米的孩子被排除在试验之外,没让他们吃。一般孩子的证据弱得多。另一项 1162 名普通母乳喂养婴儿的试验里,按分组算,早引入组食物过敏 5.6%、常规组 7.1%,差别不显著(P=0.32);只有在真正做到了的那部分孩子里才显著(2.4% 对 7.3%)。这种算法容易把效果说大,作者自己说按分组算没能证出效力,但也说明早引入是安全的。中国的官方喂养文件目前对「该早引入还是该回避易过敏食物」没有说法,所以这条按国际试验证据写。时间点上也要注意:LEAP 从 4 月龄起,而中国是满 6 月龄开始加辅食,见本节第 4 条(前 6 个月只喂母乳)。高危孩子几月龄开始、怎么开始,听医生的。

Author's scope notes: **形式只能是花生酱调稀或者花生粉拌进辅食,绝不能给整粒花生。**卫健委的喂养核心信息写得很明白:「整粒花生、坚果、果冻等食物易吸入气管,引起窒息,婴幼儿应当避免食用」。噎住了怎么办见第 13 节第 26 条(有人噎住说不出话)。适用的只是高危孩子:有重度湿疹,或者已经对鸡蛋过敏的那些。**加之前必须先看医生做评估,不要自己在家试**:LEAP 试验入组前给每个孩子做了皮试,皮试反应大于 4 毫米的孩子被排除在试验之外,没让他们吃。一般孩子的证据弱得多。另一项 1162 名普通母乳喂养婴儿的试验里,按分组算,早引入组食物过敏 5.6%、常规组 7.1%,差别不显著(P=0.32);只有在真正做到了的那部分孩子里才显著(2.4% 对 7.3%)。这种算法容易把效果说大,作者自己说按分组算没能证出效力,但也说明早引入是安全的。中国的官方喂养文件目前对「该早引入还是该回避易过敏食物」没有说法,所以这条按国际试验证据写。时间点上也要注意:LEAP 从 4 月龄起,而中国是满 6 月龄开始加辅食,见本节第 4 条(前 6 个月只喂母乳)。高危孩子几月龄开始、怎么开始,听医生的。

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Original content by eternity4719 under CC BY 4.0. English translation is credited in the source notes. HowToLiveWorse adds a clearly labeled satirical response.

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